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- ArticleGröhn P, Kuokkanen K, Krohn K.Acta Derm Venereol. 1978;58(2):153-5.A chromatographically purified component of human dialysable transfer factor, previously described as causing a non-specific stimulation of cell-mediated immunity, was used as a therapeutic agent in three cases of stage IV cystic acne. The treatment caused a marked strengthening of skin test responses and had a promising effect on skin eruption in each case.